Human apoE Isoforms Differentially Regulate Brain Amyloid- Peptide Clearance
نویسندگان
چکیده
منابع مشابه
Human apoE isoforms differentially regulate brain amyloid-β peptide clearance.
The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late-onset, sporadic Alzheimer's disease (AD). The APOE ε4 allele markedly increases AD risk and decreases age of onset, likely through its strong effect on the accumulation of amyloid-β (Aβ) peptide. In contrast, the APOE ε2 allele appears to decrease AD risk. Most rare, early-onset forms of familial AD are caused b...
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Brain neurons remove the excess of cholesterol via conversion into the more polar 24OHC [(24S)-hydroxycholesterol]. 24OHC acts as a signalling molecule inducing ApoE (apolipoprotein E)-mediated cholesterol efflux from astrocytes, by a direct effect on ApoE transcription, protein synthesis and secretion. In CSF (cerebrospinal fluid) collected form from patients with cognitive impairment (Alzheim...
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ژورنال
عنوان ژورنال: Science Translational Medicine
سال: 2011
ISSN: 1946-6234,1946-6242
DOI: 10.1126/scitranslmed.3002156